Synthetic human secretin did not improve symptoms or communication skills in children with autistic disorders

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Children with autistic spectrum disorders. I: comparison of placebo and single dose of human synthetic secretin.

AIMS To examine the effect of a single dose of human synthetic secretin (HSS) on behaviour and communication in children with autism spectrum disorder (ASD) using an objective measure of communication and social reciprocity and standardised rating scales. METHODS Randomised, crossover, double blind, and placebo controlled trial of a single intravenous dose of human synthetic secretin (HSS) 2 ...

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Repeated doses of porcine secretin did not improve symptoms, language, or cognitive functioning in children with autism or autism spectrum disorder.

Main outcome measures Assessment of symptoms of autism (Autism Behaviour Checklist and Treatment/Side Effect Behaviour Scale by parents and ADOS-G by clinicians), language (Preschool Language Scale III [PLS-3]) and ADOS-G), visual spatial attention task, and physiological and/or gastrointestinal (GI) symptoms (parent questionnaires). Cognitive function (Leiter International Performance Scale-Re...

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CHILD HEALTH SERIES Children with autistic spectrum disorders. I: Comparison of placebo and single dose of human synthetic secretin

Aims: To examine the effect of a single dose of human synthetic secretin (HSS) on behaviour and communication in children with autism spectrum disorder (ASD) using an objective measure of communication and social reciprocity and standardised rating scales. Methods: Randomised, crossover, double blind, and placebo controlled trial of a single intravenous dose of human synthetic secretin (HSS) 2 ...

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Impairment in movement skills of children with autistic spectrum disorders.

AIM We undertook this study to explore the degree of impairment in movement skills in children with autistic spectrum disorders (ASD) and a wide IQ range. METHOD Movement skills were measured using the Movement Assessment Battery for Children (M-ABC) in a large, well defined, population-derived group of children (n=101: 89 males,12 females; mean age 11y 4mo, SD 10mo; range 10y-14y 3mo) with c...

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Hyperbaric oxygen therapy may improve symptoms in autistic children.

Autism is a neurodevelopmental disorder that currently affects as many as 1 out of 166 children in the United States. Recent research has discovered that some autistic individuals have decreased cerebral perfusion, evidence of neuroinflammation, and increased markers of oxidative stress. Multiple independent single photon emission computed tomography (SPECT) and positron emission tomography (PE...

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ژورنال

عنوان ژورنال: Evidence-Based Mental Health

سال: 2000

ISSN: 1362-0347

DOI: 10.1136/ebmh.3.2.52